Three Good Multisig Operations Tips! 1) You can create multisig with Safe, and sign transactions off-chain and send them using any other wallet that doesn't control multisig at all. So, you could use Safe contract alternatively to any ERC2771 smart contracts (like Openzeppelin Defender is). 2) How to choose a better number of signers? Pick a M-of-N multisig where M is less than N, such as 2-of-3. Give yourself some leeway, a 2-of-2 requires all your backups to work perfectly. 3) Implement Web3 Front-end monitoring, use a tool by @0xKoda (link below)!